Senior Scientist of In Vivo Group 上海

月薪： 1-2万/月

该公司所有职位
  • 无工作经验
  • 招若干人
  • 英语熟练
  • 02-08 发布
  • 五险一金
  • 免费班车
  • 员工旅游
  • 餐饮补贴
  • 专业培训
  • 年终奖金
  • 股票期权
  • 弹性工作
  • 定期体检

职位描述

岗位职责： The candidates will use a wide range of advanced methodologies through in vitro, ex vivo cell-based immunological assays, and in vivo efficacy study as well as pharmacologic study. The successful candidate will have excellent oral and written communication skills, work independently as part of a team, and be able to execute on multiple projects simultaneously. With limited supervision, the role includes developing and optimizing studies in vitro, ex vivo and in vivo, and making decisions using good scientific judgment.       任职资格： BS, MS or Ph.D. in Immunology, oncology, cell biology, molecular biology, pharmacology or related fields.Training and background in immunology, immune-oncology, monoclonal antibody generation, therapeutic antibody discovery, inflammation, veterinary medicine, molecular biology and/or cell biology are preferred.Experienced in cell biology such as, cell culture and cell banking, including mouse and human tumor cell lines, primary cell and primary immune cell or tissue culture skills; experienced with PBMC and immune cell isolation, culture, activation, and characterization, as well as functional testing from healthy donors or patient-derived samples and murine lymphocytes.Able to perform immune assays (e.g., spleen and LN isolation, lymphocyte cultures and growth, MLR, antigen-specific T activation, cytokine analysis, ELISA/ELISPOT, qPCR). Data interpretation, analysis, troubleshooting, and report writing.Experience with in vivo models such as syngeneic and xenograft models in evaluating the efficacy of antibodies and small molecules, with a variety of tumor cell lines (human and mouse). Preferred with experienced in inflammation/autoimmune/tumor disease models in mouse systems, and their application towards pharmacological assessment of drug efficacy and mode-of-action. CRO experience is a plus, and experiences, such as mouse handling, drug administration, tumor measurement, blood and tissue sample collection, data analysis, and troubleshooting are considered.Experienced in FACS analysis: performed staining via fluorescent antibodies in detecting cellular products such as cytokines, proteins, and other factors similar to ELISA sandwich assays; known cytometric bead array (CBA) assays use multiple bead populations typically differentiated by size and different levels of fluorescence intensity to distinguish multiple analytes. FACS assays in apoptosis, cell surface antigens (CD markers), cell viability etc. trouble shooting in FACS analysis, proficiency in FACS machine operation and software analysis such as FlowJo.Specialized in staining Immunohistochemistry (IHC) in cells or a tissue section by exploiting the principle of antibodies binding specifically to antigens. The responsibilities includes sample tissue collection, embedding in medium, paraffin wax or cryomedia, sectioning, instrument operation commonly a microtome or cryostat; prepared the sample to maintain cell morphology, tissue architecture and the antigenicity of target epitopes; visualized an antibody-antigen interaction such as peroxidase etc. Troubleshooting and analysis, for example, reducing antibody cross-reactivity. Experienced in PK/PD models including influence dosing, benefit, and adverse effects; emphasis on dose–response relationships, that is, the relationships between drug concentration and effect; performing studies such as ELISA; knowing data analysis with software such as WinNolin, and understanding statistical analysis with Excel, or SPSS.Ability to organize and communicate complex data sets in a clear and concise manner. Willing to contribute at a scientific and strategic level to drug discovery research programs or targets in Immunology/Oncology, including proposal and reproducibility and reliability of experimental data.S/he should be a strong team player with excellent oral and written communication skills and a demonstrated ability to work independently to design experiments, generate and interpret data, troubleshoot, and suggest next steps. Demonstrated project-leading experience in an academic or industrial research setting. Demonstrated experience mentoring and training junior scientists for higher positions is a plus; proven experience with biologics drug discovery and demonstrable knowledge of large molecule formats and associated technologies is preferred.                       职能类别： 生物工程/生物制药

联系方式

上海市外高桥保税区富特中路288号

公司信息

药明生物（WuXi Biologics）是香港上市公司（代码：2269），我们是全球领先的开放式、一体化生物制药能力和技术平台，旗下包括无锡药明康德生物技术股份有限公司、上海药明生物技术有限公司、苏州药明康德检测检验有限责任公司，并在美国和英国设有子公司。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。目前，公司规模达到2300多人，有200多位拥有海外高等学位和工作经验的海归科学家，拥有丰富的欧美市场抗体开发、生产、质量控制、临床前研究和注册的经验，打造了世界一流的生物药研究、开发及生产团队。 更多信息，请登录公司官网：http://www.wuxibiologics.com.cn/

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